A vicious anaconda escapes into the remote mountains after being subjected to a new anti-cancer serum, and now Dr. Amanda Haze (Crystal Allen) and others must brave the wilderness to kill the fearsome beast. But no sooner do they cut the snake in half than it regenerates into two bloodthirsty serpents, thanks to the experimental drug. Don E. FauntLeRoy directs this creepy-crawly sequel to Anaconda 3: The Offspring. John Rhys-Davies costars.