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In Paris in the early 1990s, a group of activists goes to battle for those stricken with HIV/AIDS, taking on sluggish government agencies and major pharmaceutical companies in bold, invasive actions. The organization is ACT UP, and its members, many of them gay and HIV-positive, embrace their mission with a literal life-or-death urgency. Amid rallies, protests, fierce debates and ecstatic dance parties, the newcomer Nathan falls in love with Sean, the group s radical firebrand, and their passion sparks against the shadow of mortality as the activists fight for a breakthrough.