Uma Thurman stars as Sissy Hankshaw, whose large thumbs give her a talent for hitchhiking, in this road movie that follows Sissy as she visits a lesbian dude ranch (where she's scheduled to model for feminine hygiene advertisements) and finds love. Director Gus Van Sant's adaptation of Tom Robbins's novel features an all-star cast, including Lorraine Bracco, Angie Dickinson, Carol Kane and Keanu Reeves.