Determined to rescue his sister from a mental hospital, Jack Romero (Jesse Metcalfe) masquerades as a madman to gain entry to the asylum, where he finds a deranged sawbones (Peter Stormare) using patients as guinea pigs in bizarre experiments. To keep his involuntarily committed sibling -- and himself -- from becoming cannibalistic psychos like the doctor's other victims, Jack will need all his ingenuity in this direct-to-video splatterfest.