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After their prison barge goes down in the middle of the Caribbean, the doctor on board, Claude de Ross (Claudio Cassinelli), and a group of convicts washes ashore a remote island where mad scientist Prof. Ernest Marvin (Joseph Cotten) is conducting a series of horrific experiments. When the prisoners begin to disappear one by one, Ross suspects that they've fallen into the hands of Marvin's grotesque creations.