Season two begins 30 seconds after the final episode of the first season, Eve is reeling and Villanelle has disappeared. Eve has no idea if the woman she stabbed is alive or dead, and now both of them are in deep trouble. Eve has to find Villanelle before someone else does, but unfortunately, she's not the only person looking for her.

The story of two women with brutal pasts, addicted to each other but now trying desperately to live their lives without their drug of choice. For Villanelle, the assassin without a job, Eve is dead. For Eve, the ex-MI6 operative hiding in plain sight, Villanelle will never find her. All seems fine until a shocking and personal death sets them on a collision course yet again. The journey back to each other will cost both of them friends, family, and allegiances…and perhaps a share of their souls.