Reeling from the death of the Fourth Hokage, who sacrificed himself to defeat the evil Orochimaru, the residents of the Hidden Leaf village discover a new villain has emerged -- Sasuke's menacing brother, Itachi. When it's revealed that Itachi and his cohort, Kisame, are after the demon imprisoned in Naturo's body, Jiraiya whisks away on a quest to locate Lady Tsunade, the warrior chosen to be the fifth Hokage.