All that George (Burgess Meredith) and Lennie (Lon Chaney Jr.) want is a home of their own, where they can work for themselves and keep a pen of rabbits. But for the unlikely roommates, reality is to live a vagabond life, swinging from job to job and boss to boss. Just when it seems their dreams could come true, Lennie's simpleminded strength works against him -- and smashes George's hopes. Based on John Steinbeck's classic novel.