Common Sense Note
Parents need to know that there are some iffy messages here about sexism, thanks to the show's overly sunny and nostalgic tone. Female characters are portrayed as independent but must meet strict physical beauty standards (including regular weigh-ins); they also endure other sexist treatment from male (and a few female) colleagues that just wouldn't fly (pun intended) today. Social drinking is somewhat glamorized, too, and there's some light sexual content (mostly kissing) along with low-level language ("damn," "hell," etc.). The espionage subplot results in some tension and peril.
Sexual
Content
Some kissing, making out, and simulated sex (shoulders, etc. shown while characters are in ed). Many liasions/affairs, including between characters who are involved with/married to others. Also lots of flirtatious talk.
Violence
Some tension and peril; one of the main characters stabs a male passenger with a cocktail pick when he comes on too strong.
Language
Words like "damn" and "hell" pop up. Also body-part terms like "fanny."
Social
Behavior
The show's overall feel is nostalgic and rather sunny for a time when we traveled with service and style. But many scenes reflect the blatant sexism of the time, almost with fondness. Flight attendants (who are, of course, called "stewardesses" here) must weigh in for work, get slapped on the bottom, are told to move their "fanny," etc., which chips away at their perceived independence.
Consumerism
Pan Am is no longer functional as an airline, but its logo is everywhere in the show.
Drugs / Tobacco /
Alcohol
The airplane itself is stocked with a full, visible bar, allowing passengers to drink martinis and the like in flight. After hours, the crew regularly meets for drinks, etc.