Grace (Chloe Sevigny), a diligent journalist, is trying to write a story about Dr. Philip Lacan (Stephen Rea), a physician known for his controversial methods. But the more digging Grace does, the more she uncovers about an incredible conspiracy involving human experimentation. At Dr. Lacan's side is Angelique (Lou Doillon), an alluring woman with a mysterious past. Douglas Buck directs this remake of Brian De Palma's identically titled classic.