After his painter wife (Catherine Keener) leaves him and takes their daughter to Berlin, theater director Caden Cotard (Philip Seymour Hoffman) stages an autobiographical play in a massive New York City warehouse amid a life-size replica of Manhattan. Meanwhile, Caden must contend with the many women in his life -- including a box-office worker, an actress and a shrink -- in this beguiling directorial debut from screenwriter Charlie Kaufman.