Robert Altman's biopic delves into the lives of painter Vincent van Gogh (Tim Roth) and his dedicated brother, Theo (Paul Rhys). The story centers on the pair's relationship as gallery owner Theo struggles to promote the works of his brother, who remained a relative unknown until after his death. As Theo fails in his efforts and his financial problems mount, Vincent's disturbed mental state worsens, and both brothers sink into despair.