A follow-up to "Young Buffalo Bill," featuring Roy Rogers as Bill Hickok. Foreigners -- led by Nicholas Tower (John Miljan), who enlists a ruthless mob to do his work for him -- attempt to take over the West, and it's up to Hickok to prevent it. At first, Louise Mason (Jacqueline Wells) supports Tower, but she changes her stance when she finds out what he has planned. Sally Payne co-stars as Calamity Jane, and "Gabby" Hayes also turns up.