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Writer-director Neil LaBute's misanthropic black comedy stars Amy Brenneman, Aaron Eckhart, Catherine Keener, Jason Patric, Ben Stiller and Nastassja Kinski as a web of friends, acquaintances and lovers intertwined in complex, shifting relationships. A theater instructor's lack of prowess frustrates his wife, who in turn has an affair with a lesbian art gallery worker. Meanwhile, a sadistic doctor tries to persuade his married friend to ditch monogamy.