Kelly Hankins is the heartthrob of Butterhill High. He has a secret love affair with Lisa Weld, which is strictly forbidden by her father Reverend Weld. Their secret becomes a growing problem when Lisa becomes pregnant and looks to Kelly to rescue her. While visiting his eccentric uncle, Kelly discovers a solution to their dilemma when he sees his uncle's latest experiment Adam, a male monkey who has received an embryo transfer and is carrying a baby. Kelly decides to become the first human experiment. High School life becomes increasingly tough over the course of the next several months as Kelly attempts to hide his metamorphosis into Mamaboy!