Wilson studied her craft at New York University's Tisch School of the Arts and at the Lee Strasberg Theatre Institute. She broke into television in 1989 in an episode of "The Cosby Show"; supporting roles in feature films ensued, including the 1993 AIDS drama Philadelphia (with Tom Hanks) and Lone Star (1996).
After a string of guest-star gigs on TV shows such as "Sex and the City," "The Sopranos" and "Law & Order: Special Victims Unit," Wilson landed in her own series: the phenomenally successful "Grey's Anatomy." Playing the sharp-tongued Miranda Bailey, Wilson snagged multiple Emmy nods for Best Supporting Actress in a Drama. She also scored an Emmy nod for her role as a homeless person in the TV movie Accidental Friendship.
When two men discover a human skull and an encrusted badge buried near a small Texas border town, lawman Sam Deeds (Chris Cooper) launches an investigation that reveals a 40-year-old murder in director John Sayles's acclaimed drama. Sam's late father, the former sheriff (Matthew McConaughey, in flashbacks), is a town legend, and Sam's discoveries threaten to tarnish his dad's reputation and touch the lives of nearly everyone in the community.