But the actress truly seemed to hit her stride in her 30s, racking up an Emmy-winning guest stint as Jennifer Aniston's younger sister on "Friends" (2002-03); a Tony nod as the title character in "Sweet Charity" on Broadway; and a couple Emmy nominations for playing a recovering amnesiac on "Samantha Who?"
When it comes to big-screen comedy, Applegate has proved equally adept. She stepped as Cameron Diaz's best friend in The Sweetest Thing (2002) and also played the straight woman to an outrageous Will Ferrell in Anchorman: The Legend of Ron Burgundy (2004).
Looking behind the veneer of perfection sought by modern American mothers, this comic tale follows a trio of fed-up, underappreciated suburban moms as they set out to liberate themselves, leaving their parental responsibilities behind.
- Youth In Oregon
- Alvin and the Chipmunks: Chipwrecked
- Cats & Dogs: The Revenge of Kitty Galore
- The Book of Life
- Hall Pass
- Anchorman: The Legend of Ron Burgundy
- Don't Tell Mom the Babysitter's Dead
- Anchorman 2: The Legend Continues
- Going the Distance
- Prince Charming
- Employee of the Month
- Alvin and the Chipmunks: The Squeakquel
- Married... with Children
- Surviving Christmas
- The Rocker
- I Am Chris Farley
- The Big Hit
- Grand Theft Parsons
- Samantha Who?
- Married... with Children: Vol. 2
- The Brutal Truth
- MTV: Punk'd: Season 1
- View from the Top
- Farce of the Penguins
- Up All Night