But the actress truly seemed to hit her stride in her 30s, racking up an Emmy-winning guest stint as Jennifer Aniston's younger sister on "Friends" (2002-03); a Tony nod as the title character in "Sweet Charity" on Broadway; and a couple Emmy nominations for playing a recovering amnesiac on "Samantha Who?"
When it comes to big-screen comedy, Applegate has proved equally adept. She stepped as Cameron Diaz's best friend in The Sweetest Thing (2002) and also played the straight woman to an outrageous Will Ferrell in Anchorman: The Legend of Ron Burgundy (2004).
Looking behind the veneer of perfection sought by modern American mothers, this comic tale follows a trio of fed-up, underappreciated suburban moms as they set out to liberate themselves, leaving their parental responsibilities behind.
- Youth In Oregon
- The Book of Life
- Alvin and the Chipmunks: Chipwrecked
- Cats & Dogs: The Revenge of Kitty Galore
- Anchorman: The Legend of Ron Burgundy
- Anchorman 2: The Legend Continues
- I Am Chris Farley
- Hall Pass
- Prince Charming
- The Big Hit
- The Rocker
- Married... with Children: Vol. 2
- Don't Tell Mom the Babysitter's Dead
- Samantha Who?
- Alvin and the Chipmunks: The Squeakquel
- Married... with Children
- The Brutal Truth
- Grand Theft Parsons
- MTV: Punk'd: Season 1
- View from the Top
- Going the Distance
- Up All Night
- Surviving Christmas
- Employee of the Month
- Farce of the Penguins