But the actress truly seemed to hit her stride in her 30s, racking up an Emmy-winning guest stint as Jennifer Aniston's younger sister on "Friends" (2002-03); a Tony nod as the title character in "Sweet Charity" on Broadway; and a couple Emmy nominations for playing a recovering amnesiac on "Samantha Who?"
When it comes to big-screen comedy, Applegate has proved equally adept. She stepped as Cameron Diaz's best friend in The Sweetest Thing (2002) and also played the straight woman to an outrageous Will Ferrell in Anchorman: The Legend of Ron Burgundy (2004).
Looking behind the veneer of perfection sought by modern American mothers, this comic tale follows a trio of fed-up, underappreciated suburban moms as they set out to liberate themselves, leaving their parental responsibilities behind.
- Youth In Oregon
- The Book of Life
- Cats & Dogs: The Revenge of Kitty Galore
- Alvin and the Chipmunks: Chipwrecked
- Anchorman: The Legend of Ron Burgundy
- Anchorman 2: The Legend Continues
- Don't Tell Mom the Babysitter's Dead
- I Am Chris Farley
- Alvin and the Chipmunks: The Squeakquel
- The Big Hit
- Going the Distance
- The Rocker
- Hall Pass
- Married... with Children
- Prince Charming
- View from the Top
- Up All Night
- MTV: Punk'd: Season 1
- Farce of the Penguins
- Married... with Children: Vol. 2
- The Brutal Truth
- Grand Theft Parsons
- Employee of the Month
- Surviving Christmas
- Samantha Who?