But the actress truly seemed to hit her stride in her 30s, racking up an Emmy-winning guest stint as Jennifer Aniston's younger sister on "Friends" (2002-03); a Tony nod as the title character in "Sweet Charity" on Broadway; and a couple Emmy nominations for playing a recovering amnesiac on "Samantha Who?"
When it comes to big-screen comedy, Applegate has proved equally adept. She stepped as Cameron Diaz's best friend in The Sweetest Thing (2002) and also played the straight woman to an outrageous Will Ferrell in Anchorman: The Legend of Ron Burgundy (2004).
Looking behind the veneer of perfection sought by modern American mothers, this comic tale follows a trio of fed-up, underappreciated suburban moms as they set out to liberate themselves, leaving their parental responsibilities behind.
- Youth In Oregon
- Alvin and the Chipmunks: Chipwrecked
- Cats & Dogs: The Revenge of Kitty Galore
- The Book of Life
- Don't Tell Mom the Babysitter's Dead
- Anchorman: The Legend of Ron Burgundy
- Hall Pass
- Anchorman 2: The Legend Continues
- View from the Top
- Alvin and the Chipmunks: The Squeakquel
- Going the Distance
- I Am Chris Farley
- The Big Hit
- Married... with Children
- Grand Theft Parsons
- MTV: Punk'd: Season 1
- Surviving Christmas
- Employee of the Month
- The Rocker
- Married... with Children: Vol. 2
- The Brutal Truth
- Prince Charming
- Farce of the Penguins
- Samantha Who?
- Up All Night