Soon after his cross-country move, Roth sold his animated series "Chowdaheads" -- which he co-wrote, directed and produced -- but the show never aired. He found success a few years later, however, when he incorporated his medical maladies into the chilling cult favorite Cabin Fever. Roth's next feature, Hostel (2006), struck box-office gold and spawned a sequel in 2007.
Stepping out from behind the camera, Roth muscled up and took on the supporting role of skull-cracker Donnie Donowitz in 2009's Inglourious Basterds. Roth's subsequent work includes directing and executive-producing the Netflix original series "Hemlock Grove."
A Jewish cinema owner (Mélanie Laurent) in occupied Paris is forced to host a Nazi movie premiere, where a radical group of American Jewish soldiers called the Basterds, led by Lt. Aldo Raine (Brad Pitt), plans to roll out a score-settling scheme.