Shifting gears in 1986, Perkins bowed on the silver screen as Demi Moore's razor-tongued best friend in About Last Night.... Two years later, Perkins landed her breakthrough role starring opposite Tom Hanks in the box-office hit Big, and she wowed critics with her fine portrayal of a terminal cancer patient in 1991's The Doctor. But her biggest success came with the live-action version of The Flintstones (1994).
Perkins tackled series television in 2000 with the short-lived "Battery Park" but had better luck in 2005 with the highly rated cable series "Weeds." For her supporting work on the show, she earned multiple Emmy and Golden Globe nods.
In this Oscar-winning animated adventure, plucky fish Marlin and Dory search their underwater world for Marlin's missing son, Nemo, who's been scooped up by a scuba diver and dumped in a dentist's aquarium.