Several years after moving to New York City, Knight bagged a role on Broadway opposite Patti LuPone and Peter Gallagher in a revival of "Noises Off" (2001). Knight made his film debut in Garmento before returning to the stage in 2003 in "Scattergood." Small television roles on "Frasier," "Law & Order: Criminal Intent" and "CSI: Crime Scene Investigation" soon followed.
But it was Knight's portrayal of likable surgical intern George O'Malley on the hit TV series "Grey's Anatomy" that finally brought the actor national notoriety, including an Emmy nomination in 2007.
This biopic focuses on the relationship between baseball icon Jackie Robinson and Brooklyn Dodgers general manager Branch Rickey, who signed Robinson and in 1947 made him the first black Major League Baseball player of the modern era.